The following are fructose related literature reviews, as well as comments from the Calorie Control Council in response to misinformation about fructose in the media. The articles below are listed alphabetically by author under the topic of the article.
Body Weight
- Daniells S. Food industry dooms children to obesity, says scientist. Food Navigator, 2006.
Click here to read the Calorie Control Council’s comments (pdf)
- Johnson R. Havel P. Watch what you put in that sippy cup, experts warn. ScienceDaily.com, 2007.
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- Jürgens H, et al. Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res 2005 Jul;13:1146-56.
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- Komaroff A. Added sweeteners: Are High fructose corn syrup and other sweeteners fueling the American obesity epidemic? Harvard Health Letter. 2006 (12):1-3.
Click here to read the Calorie Control Council’s comments (pdf)
- Marinello N. Sticky Sweet: Corn syrup delivers overload of fructose. TimesUnion.com, 2007.
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- Otto B, Nawrocki AR, Scherer PE, et al. Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res. 2005 Jul;13:1146-56.
Click here to read the Calorie Control Council’s comments (pdf)
- Shapiro A, Mu W, Roncal CA, Cheng K-Y, Johnson RJ, Scarpace PJ. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high fat feeding. Am J Physiol Regul Integr Comp Physiol. 2008:00195.2008.
Click here to read the Calorie Control Council’s comments (pdf)
Diabetes
- Calorie Control Council. Response to Sanchez-Lozada et al. Editorial: how safe is fructose for persons with or without diabetes. 2008.
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- Choi ME. The not-so-sweet side of fructose. J Am Soc Nephrol 2009;20:457-9.
Click here to read the Calorie Control Council’s comments (pdf) - Montonen J, Jarvinen R, Knekt P, Heliovaara M, Reunanen A. Consumption of sweetened beverages and intakes of fructose and glucose predict type 2 diabetes occurrence. J Nutr 2007;137:1447-54.
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- Nagai Y, Yonemitsu S, Erion DM, et al. The role of peroxisome proliferator-activated receptor γ coactivator-1 β in the pathogenesis of fructose-induced insulin resistance. Cell Metab 2009;9:252-64.
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Gout
- Choi HK, Curhan G. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study. Brit Med J. 2008 Feb 9;336:309-12.
Click here to read the Calorie Control Council’s comments (pdf)
- Doherty M. New insights into the epidemiology of gout. Rheumatology (Oxford) 2009;48:ii2-ii8.
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- Underwood M. Sugary drinks, fruit, and increased risk of gout. Brit Med J. 2008;336:285-286.
Click here to read the Calorie Control Council’s comments (pdf)
Metabolic Syndrome
- Cirillo P, Sautin YY, Kanellis J, et al. Systemic inflammation, metabolic syndrome and progressive renal disease. Nephrol Dial Transplant 2009; 24:1384–1387.
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- Miller A, Adeli K. Dietary fructose and the metabolic syndrome. Curr Opin Gastroenterol. 2008 Mar;24:204-9.
Click here to read the Calorie Control Council’s comments (pdf)
- N. Roglans, L. Vil, M. Farr, M. Alegret, R.M. Sanchez, M. Vazquez-Carrera, and J.C. Laguna. Impairment of hepatic Stat-3 activation and reduction of PPAR-alpha activity in fructose-fed rats. Hepatology. 45(3): 778 – 788, 2007.
Click here to read the Calorie Control Council’s comments (pdf)
Metabolism
- Hand B. Diet danger: High fructose corn syrup, the effects of corn syrup aren't so sweet. SparkPeople-Nutrition Section, 2005.
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- Is fructose bad for you? Harvard Health Letter, 2006.
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- Warner M. A Sweetener with a Bad Rap. New York Times, 2006.
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Plasma lipids
- C. Chotiwat , C. Sharp, K. Teff and R.B.S. Harris. Feeding a high-fructose diet induces leptin resistance in rats. Appetite. 2007; 49: 284.
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- Couchepin C, Le KA, Bortolotti M, da Encarnacao JA, Oboni JB, Tran C, Schneiter P, Tappy L. Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects: Diabetes Care. 2008 Jun;31:1254-6.
Click here to read the Calorie Control Council’s comments (pdf)
- Le KA, Ith M, Kreis R, et al. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr 2009;89:1760-5.
Click here to read the Calorie Control Council’s comments (pdf)
- Parks EJ, Skokan LE, Timlin MT, Dingfelder CS. Dietary sugars stimulate fatty acid synthesis in adults. J Nutr.2008 Jun;138:1039-46.
Click here to read the Calorie Control Council’s comments (pdf)
- Stanhope KL, Griffen S, Keim NL, Ai M, Otokozawa S, Nakajima K, Schaefer EJ and Havel PJ. Consumption of fructose-but not glucose-sweetened beverages produces an atherogenic lipid profile in overweight/obese men and women. 67th Annual Scientific Session of the American Diabetes Association. Chicago, IL, 2007:Abstract 0062-OR.
Click here to read the Calorie Control Council’s comments (pdf)
- Stanhope, K.L., Schwarz, J.M., Keim, N.L., Griffen, S.C., Bremer, A.A., Graham, J.L., Hatcher, B., Cox, C.L., Dyachenko, A., Zhang, W., et al. 2009. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 119:1322-1334
Click here to read the Calorie Control Council’s comments (pdf) - Teff KL, Grudziak J, Townsend RR, et al. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab 2009; 94: 1562-1569.
Click here to read the Calorie Control Council’s comments (pdf)
Potential Benefits of Fructose
- According to the Calorie Control Council, Research Just Released Supports the Benefits of Fructose
Click here to read the Calorie Control Council’s comments (pdf)
- Kellow J. A Little Sweetener. Daily Mirror, 2006.
Click here to read the Calorie Control Council’s comments (pdf)
- Livesey G, Taylor R. Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight; meta-analysis and meta-regression models of intervention studies. Am J Clin Nutr. 2008;88:1419-37.
Click here to read the meta-analysis (pdf)
- Angelopoulos T, Lowndes J, Zukley L, Melanson K, Nguyen V, Huffman A, Rippe J.
J. Nutr. 2009 139: 1242S-1245S.
Click here to read the study abstract
- Bantle J.
J. Nutr. 2009 139: 1263S-1268S.
Click here to read the study abstract
- Borra S, Bouchoux A.
J. Nutr. 2009 139: 1214S-1218S.
Click here to read the study abstract
- Jones J.
J. Nutr. 2009 139: 1210S-1213S.
Click here to read the study abstract
- Livesey G.
J. Nutr. 2009 139: 1246S-1252S.
Click here to read the study abstract
- Marriott B, Nancy Cole N, Lee E.
J. Nutr. 2009 139: 1228S-1235S.
Click here to read the study abstract
- Moran T.
J. Nutr. 2009 139: 1253S-1256S.
Click here to read the study abstract
- Murphy S.
J. Nutr. 2009 139: 1269S-1270S.
Click here to read the study abstract
- Schaefer E, Gleason J, Dansinger M.
J. Nutr. 2009 139: 1257S-1262S.
Click here to read the study abstract
- Stanhope K, Havel P.
J. Nutr. 2009 139: 1236S-1241S.
Click here to read the study abstract
- White J.
J. Nutr. 2009 139: 1219S-1227S.
Click here to read the study
Other Medical Conditions
- Gersch MS, Mu W, Cirillo P, Reungjui S, Zhang L, Roncal C, Sautin YY, Johnson RJ, Nakagawa T. Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am J Physiol Renal Physiol. 2007 Oct;293:F1256-61.
Click here to read the Calorie Control Council’s comments (pdf)
- Howard B. Sugar or Sweetener? Sucrose has its problems, but so do artificial substitutes. The Environmental Magazine, 2006.
Click here to read the Calorie Control Council’s comments (pdf)
- Lane MD, Cha SH. Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain. Biochem Biophys Res Commun 2009; 382: 1-5.
Click here to read the Calorie Control Council’s comments (pdf) - Lê KA, Faeh D, Stettler R, Debard C, Loizon E, Vidal H, Boesch C, Ravussin E, Tappy L. Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34:82-5.
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- Nguyen S, Choi HK, Lustig RH, Hsu CY. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr 2009;154:807-13.
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- Nothlings, Murphy, Wilkens, Henderson, Kolonel. Dietary glycemic load, added sugars, and carbohydrates as risk factors for pancreatic cancer: the multiethnic cohort study. Am J Clin Nutr.2007;86:1495-1501.
Click here to read the Calorie Control Council’s comments (pdf)
- Squires S. Stealth Calories. Washington Post, 2007.
Click here to read the Calorie Control Council’s comments (pdf)
- Thuy S, Ladurner R, Volynets V, Wagner S, Strahl S, Konigsrainer A, Maier KP, Bischoff SC, Bergheim I. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr 2008 Aug;138:1452-5.
Click here to read the Calorie Control Council’s comments (pdf)